STKE:Of Arsenic and NF- B

NF- B and FLIP in arsenic trioxide (ATO)–induced apoptosis in myelodysplastic syndromes (MDSs)

Tumor necrosis factor (TNF)– , a potent stimulus of nuclear factorB (NFB), is up-regulated in myelodysplastic syndrome (MDS). Here, we show that bone marrow mononuclear cells (BMMCs) and purified CD34 cells from patients with low-grade/early-stage MDS (refractory anemia/refractory anemia with ring sideroblasts [RA/RARS]) have low levels of NFB activity in nuclear extracts comparable with normal...

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Signaling to NF - B

A firm hand on NF B: structures of the I B –NF B complex

The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...

NF- B and AP-1 Connection: Mechanism of NF- B-Dependent Regulation of AP-1 Activity